Bactrim Online
Bactrim is a combination bactericidal chemotherapeutic agent. International name is Co-trimoxazole. Combined antimicrobial is agent consisting of sulfamethoxazole and trimethoprim. Sulfamethoxazole, which is similar in structure to PABA, violates the synthesis digidrofolievoy acids in bacterial cells, preventing the incorporation of PABA in its molecule. Trimethoprim sulfamethoxazole increases the effect of, violating the recovery digidrofolievoy tetrahydrofolic acid - the active form of folic acid, which is responsible for protein metabolism and microbial cell division.
Patients with impaired renal function are necessary to adjust the dose according to creatinine clearance. With careful use, with possible folate deficiency, aggravated by allergic history, asthma, liver problems and thyroid zhelezy, cough, arthralgia and other symptoms of reception should be stopped immediately. Long-term assignment is carried out with systematic monitoring of cellular composition of peripheral blood, the functional state of the liver and kidneys. In order prevent crystalluria abundant alkaline pite. Sledded recommended avoid excessive sun and UV exposure. The risk of side effects is significantly higher in patients with AIDS. Contraindications: Hypersensitivity (includingto sulfonamides or trimethoprim), hepatic or renal insufficiency, B12-deficiency anemia, agranulocytosis, leukopenia, deficiency of glucose-6-phosphate dehydrogenase, pregnancy, lactation, infancy (up to 2 months - for oral, up to 6 years - for parenteral administration) ,hyperbilirubinemia in children.
It is desirable to determine the concentration of sulfamethoxazole in plasma every 2-3 days immediately before the next infusion. If the concentration of sulfamethoxazole exceeds 150 mcg / mL, treatment should be interrupted as long as it does not fall below 120 mg / ml. During long-term (over months) courses of treatment need regular blood tests, because there is the likelihood of hematological changes (often asymptomatic).These changes can be reversed, with the appointment of folic acid (3-6 mg / day), which essentially does not affect the antimicrobial activity of the drug. Particular caution should be manifested in the treatment of elderly patients or patients with a suspected initial lack of folate.Appointment of folic acid are also advisable during prolonged treatment with high doses. To prevent crystalluria is recommended to maintain a sufficient amount of urine.
Buy Bactrim online or in stores. The likelihood of toxic and allergic complications of sulfonamides is significantly increased with a decrease in renal filtration. Also impractical to use during the treatment foods containing large amounts of PABA - the green parts of plants (cauliflower, spinach, beans), carrots, tomatoes. You should avoid excessive sun and UV irradiation. The risk of side effects is significantly higher in patients with AIDS. Not recommended for tonsillitis and pharyngitis caused by beta-hemolytic streptococcus group A, because of widespread resistance strains.
