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V-Tada quickly absorbed at a reception inward. After a reception into the single dose of Tm�� makes from 30 mines to 6 (on the average 2), absolute bioavailability is not certain. Speed and degree of absorption do not depend on eating. Middle seeming volume of distribution after a reception inward is approximately, that specifies on that V-Tada is distributed in fabrics. At therapeutic concentrations 94% V-Tada related to the squirrel of plasma. V-Tada and penetrate through a placenta, that shows up in affecting fruit for rats. V-Tada is secreted in milk of rats and create concentrations approximately in 2, 4 time exceeding discovered in plasma. After a reception into a single dose 10 mgs/of kg approximately 0, 1% of the general entered radio-activity is excreted in milk during 3. It unknown whether V-Tada is excreted and/or him in pectoral milk for women. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and the smooth muscle of the corpus cavernosum. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP relaxes smooth muscle and increases blood flow to the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP.
V-Tada (sildenafil and vardenafil) inhibits PDE5. However, because sexual stimulation is required to initiate the local penile release of nitric oxide,V-Tada inhibition of PDE5 will have no effect without direct sexual stimulation of the penis. Due to its 36-hour effect it is also known as the weekend pill. As with sildenafil and vardenafil, it is recommended that tadalafil be used no more than once daily. V-Tada is also currently undergoing Phase 3 clinical trials for the treatment of pulmonary arterial hypertension.
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