Cytotec Online
Cytotec is a gastroprotective agent, a synthetic analogue PgE1. Increases the formation of protective mucus and bicarbonate, enhances blood flow in the mucosa. Accelerates the healing is of erosions, ulcers and 12 duodenal ulcers, in some cases able to prevent their formation. Exerting a direct effect on gastric parietal cells, inhibits basal, nocturnal, stimulated (food, histamine, pentagastrin) secretion of HCl. Reduces the basal (not stimulated by histamine) produce pepsin. The action begins in 30 minutes and lasts for at least 3-6 hours.
At a dose of 50 mg effects are mild and short, 200 mg - pronounced. Increases the frequency and force is of contraction of myometrium, the smooth muscle of the intestine. In the appointment of women of childbearing age should carry out pre-serum pregnancy test, which must remain negative for 2 weeks before taking the drug. Treatment can be started only 2-3 days after onset of menstruation. Throughout the time of receipt should use reliable methods of contraception.
Please be aware that misoprostol increases uterine tone and may because miscarriage. It should be used with caution if you have diarrhea because of the possibility of dehydration and the associated increase in the concentration of the drug. Saytotek rapidly absorbed (food delays the absorption).The walls of the gastrointestinal tract and liver biotransformation misoprostol and misoprostol acid active forms. Cmax is created after an average of 12 minutes; misoprostol is circulating in the system in the bloodstream bound to proteins (90%) form.
The equilibrium concentration of misoprostol in plasma is reached within 2 days, accumulation was observed. 80% of the dose was excreted in the urine (with impaired renal function may increase Cmax - almost 2-fold, to lengthen the T1 / 2).Used with caution in patients with arterial hypertension, ischemic heart disease, stroke, epilepsy, enterocolitis, diarrhea, hypersensitivity to prostaglandins or their analogues. Application for termination of pregnancy, in combination with mifepristone and only in specialized hospitals with appropriately trained medical personnel, and the capacity to provide emergency obstetric and surgical blood transfusion services.
Within 1 week after taking misoprostol should not be given aspirin or other NSAIDs. Application saytoteka contraindicated in hepatic dysfunction, inflammatory bowel disease, as well as children less than 18 years of age and pregnant women. Relative contraindications are diseases of the vessels of the heart and brain. Patients with kidney disease, in violation of the excretory function; you can use the drug in small doses under strict medical supervision.
