Cheap Neurontin
Neurontin is a white capsule, marked with "Neurontin 100 mg" and "PD"; content capsules are white or pale white powder. The active substance is gabapentin. Gabapentin is similar in structure GABA, but its mechanism of action differs from that of some other drugs that interact with GABA-receptors, including valproate, barbiturates, benzodiazepines, GABA-transaminase inhibitors, inhibitors of capturing GABA, agonists and GABA prodrugs of GABA: he does not possess GABA-ergic properties and does not affect the capture and metabolism of GABA. Gabapentin clearance from plasma is reduced in the elderly and patients with impaired renal function.
The rate constant of elimination, clearance from the plasma and renal clearance are directly proportional to spacecraft. Gabapentin is removed from plasma by hemodialysis. In patients with impaired renal function and patients receiving hemodialysis, dosage adjustment is recommended. After oral administration, Cmax of gabapentin in plasma is reached within 2-3 h. The bioavailability of gabapentin is not proportional to the dose, so, with increasing doses, it decreases. The absolute bioavailability of gabapentin capsules is about 60%. Food, includingwith a high content of fat, has no effect on pharmacokinetics. Excretion of gabapentin plasma is linear.
Although the use of Neurontin withdrawal were observed with the development of seizures, however, abrupt discontinuation of therapy, anticonvulsant drugs in patients with partial seizures can provoke the development of seizures. Neurontin is generally not considered effective in the treatment of epilepsy-absans. When combined therapy with morphine may need to increase the concentration of gabapentin. It is necessary to ensure careful monitoring of patients for the development of the trait CNS depression as drowsiness. In this case, the dose of Neurontin or morphine should be adequately reduced. When adding Neurontin to other anticonvulsant drugs have been reported false-positive results in the determination of protein in the urine using test strips Ames N-Multistix SG. With simultaneous use of Neurontin and morphine (morphine when taken 2 hours before taking Neurontin), an increase in the mean AUC of gabapentin by 44% compared with monotherapy Neurontin, which was accompanied by an increase in pain threshold (cold pressor test).
The clinical significance of this change has not been established, the pharmacokinetic characteristics of morphine is not altered. Side effects of morphine at a joint reception with Neurontin did not differ from those when taking morphine with placebo. You can buy Neurontin in conventional pharmacies, but buying online you save time and money. This is very beneficial to all parties. You can without spending the time to read the abstract or the seller to choose a more suitable product in a relaxed atmosphere. Neurontin can be bought only on prescription.
